関東化学株式会社 TOP R&D Publications

Publications

Our company actively promotes joint researches with universities, public institutions and companies in various fields. Below are some of the recent publications.

Organic synthesis and catalysts

  • Asymmetric Transfer Hydrogenative Amination of Benzylic Ketones Catalyzed by Cp*Ir(III) Complexes Bearing a Chiral N-(2-Picolyl)sulfonamidato Ligand
    T.Kawada, K.Yabushita, T.Yasuda, T.Ohta, T.Yajima, K.Tanaka, N.Utsumi, M.Watanabe, K.Murata, Y.Kayaki, S.Kuwata, and T.Katayama
    The Journal of Organic Chemistry, 87(13), 8458-8468(2022)
  • Reductive Amination of Ketonic Compounds Catalyzed by Cp*Ir(III) Complexes Bearing a Picolinamidato Ligand
    K.Tanaka, T.Miki, K.Murata, A.Yamaguchi, Y.Kayaki, S.Kuwata, T.Ikariya, M.Watanabe
    The Journal of Organic Chemistry, 84, 10962-10977(2019).
  • Asymmetric Hydrogenation of Polysubstituted Aromatic Ketones Catalyzed by the DIPSkewphos/PICA Derivative–Ruthenium(II) Complexes
    N.Utsumi, N.Arai, K.Kawaguchi, T.Katayama, T.Yasuda, K.Murata, T.Ohkuma
    ChemCatChem, 10(18), 3955-3959, 2018.
  • Computationally-Led Ligand Modification using Interplay between Theory and Experiments: Highly Active Chiral Rhodium Catalyst Controlled by Electronic Effects and CH-π Interactions
    T. Korenaga, R. Sasaki, T. Takemoto, T. Yasuda, M. Watanabe
    Advanced Synthesis & Catalysis, 360, 322-333,(2018).
  • Palladium-Catalyzed Decarbonylative Cross-Coupling of Azinecarboxylates with Arylboronic Acids
    K. Muto, T. Hatakeyama, K. Itami, J. Yamaguchi
    Organic Letters, 18(19), 5106-5109 (2016).
  • C-H arylation and alkenylation of imidazoles by nickel catalysis : solvent-accelerated imidazole C-H activation
    K. Muto, T. Hatakeyama, J. Yamaguchi, K. Itami
    Chemical Science, 6, 6792-6798 (2015).
  • Hydrogenation of nitroarenes with palladium nanoparticles stabilized by alkyne derivatives in homogeneous phase
    N. Arai, N. Onodera, A. Dekita, J. Hori, T. Ohkuma
    Tetrahedron Letters, 56(25), 3913-3915 (2015).

Organic materials

  • Novel Hole-Transporting Materials with High Triplet Energy for Highly Efficient and Stable Organic Light-Emitting Diodes
    H. Fukagawa, T. Shimizu, H. Kawano, S. Yui, T. Shinnnai, A. Iwai, K. Tsuchiya, T. Yamamoto
    The Jounal of Physical Chemistry C, 120(33), 18748-18755 (2016).

Inorganic materials

  • Iron Chromatographic Decontamination of 137Cs-enriched Fly Ash Using Poly(vinyl alcohol)-bound Copper Ferrocyanide as Cs Adsorbent
    T.Ichikawa, K.Yamada, R.Iwai, Y.Kanazawa
    Journal of the Society for Remediation of Radioactive Contamination in the Environment, 8(2), 55-66(2020).
  • Analysis of Cs-adsorption behavior using a column filled with microcapsule beads of potassium copper hexacyanoferrate
    G. Kido, M. Takasaki, K. Minami, H. Tanaka, H. Ogawa, T. Kawamoto, K. Yoshino
    Journal of nuclear science and technology, 54(11), 1157-1162 (2017).
  • Decomposition of Iron Hexacyabnoferrate Microcapsule Beads Using Superheated Steam
    K. M. Lee, M. Asai, T. Uchida, T. Kawamoto, K. Minami, A. Takahashi, D. Parajuli, G. Kido, M. Takasaki, K. Yoshino, H. Tanaka
    Chemistry Letters, 45(6), 670-672 (2016).
  • Improved adsorption properties of granulated copper hexacyanoferrate with multi-scale porous networks
    K. M. Lee, T. Kawamoto, K. Minami, A. Takahashi, D. Parajuli, G. Kido, K. Yoshino, H. Tanaka
    RSC Advances, 6, 16234-16238 (2016).
  • Comparative study of the factors associated with the application of metal hexacyanoferrates for environmental Cs decontamination
    D. Parajuli, A. Takahashi, H. Noguchi, A. Kitajima, H. Tanaka, M. Takasaki, K. Yoshino, T. Kawamoto
    Chemical Engineering Journal, 283, 1322-1328 (2016).
  • Application of Prussian blue nanoparticles for the radioactive Cs decontamination in Fukushima region
    D.Parajuli, A.Kitajima, A.Takahashi, H.Tanaka, H.Ogawa, Y.Hakuta, K.Yoshino, T.Funahashi, M.Yamaguchi, M.Osada, T.Kawamoto
    Journal of Environmental Radioactivity, 151, 233-237 (2016).
  • Prussian blue (PB) granules for cesium (Cs) removal from drinking water
    G. Ru. Chen, Y. R. Chang, X. Liu, T. Kawamoto, H. Tanaka, A. Kitajima, D. Parajuli, M. Takasaki, K. Yoshino, M. L. Chen, Y. K. Lo, Z. Lei, D. J. Lee
    Separation and Purification Technology, 143, 146-151 (2015).

Cell culture

  • Generation of human-induced pluripotent stem cell-derived functional enterocyte-like cells for pharmacokinetic studies
    S.Yoshida, T.Honjo, K.Iino, R.Ishibe, S.Leo, T.Shimada, T.Watanabe, M.Ishikawa, K.Maeda, H.Kusuhara, N.Shiraki, S.Kume
    Stem Cell Reports, Vol.16, 1–14(2021).
  • A live imaging-friendly slice culture method using collagen membranes
    A.Ogaki, T.Araki, M.Ishikawa, Y.Ikegaya, R.Koyama
    Neuropsychopharmacology Reports, 40, 307–313(2020).
  • Multi-laboratory Validation Study of the Vitrigel-Eye Irritancy Test Method as an Alternative to In Vivo Eye Irritation Testing
    H.Kojima, H.Yamaguchi, T.Sozu, N.Kleinstreuer, L.Chae-Hyung, W.Chen, M.Watanabe, T.Fukuda, K.Yamashita, T.Takezawa
    Alternatives to Laboratory Animals, 47(3-4),140-157(2019).
  • Collagen vitrigel promotes hepatocytic differentiation of induced pluripotent stem cells into functional hepatocyte-like cells
    S.Nakai, I.Shibata, T.Shitamichi, H.Yamaguchi, N.Takagi, T.Inoue, T.Nakagawa, J.Kiyokawa, S.Wakabayashi, T.Miyoshi, E.Higashi, S.Ishida, N.Shiraki, S.Kume
    Biology Open , 8, bio042192(2019).
  • Fabrication of a corneal model composed of corneal epithelial and endothelial cells via a collagen vitrigel membrane functioned as an acellular stroma and its application to the corneal permeability test of chemicals
    H. Yamaguchi, T. Takezawa
    Drug Metabolism and Disposition, 46(11), 1684-1691(2018).
  • Predictive performance of the Vitrigel-eye irritancy test method using 118 chemicals
    H. Yamaguchi, H. Kojima, T. Takezawa
    Journal of Applied Toxicology, 36(8), 1025-1037 (2016).
  • Fluid dwell impact induces peritoneal fibrosis in the peritoneal cavity reconstructed in vitro
    Aoki, M. Noguchi, T. Takezawa, S. Ikeda, K. Uchihashi, H. Kuroyama, T.Cimuro, S. Toda
    Journal of Artificial Organs, 19(1), 87-96 (2016).

Genetic engineering / Other

  • Molecular and Epidemiological Characterization of Emerging Immune-Escape Variants of SARS-CoV-2
    K.Miyakawa, S.S.Jeremiah, Y.Yamaoka, T.Koyama, R.Tokumasu, M.Kudo, H.Kato, A.Ryo
    frontiers in Medicine, 10(2022).
  • Antibody titers against the Alpha, Beta, Gamma, and Delta variants of SARS-CoV-2 induced by BNT162b2 vaccination measured using automated chemiluminescent enzyme immunoassay
    H.Kato, K.Miyakawa, N.Ohtake, H.Go, Y.Yamaoka, S.Yajima, T.Shimada, A.Goto, H.Nakajima, A.Ryo
    Journal of Infection and Chemotherapy, 28, 273–278(2022).
  • Phosphopeptide enrichment using Phos-tag technology reveals functional phosphorylation of the nucleocapsid protein of SARS-CoV-2
    Y.Ino, M.Nishi, Y.Yamaoka, K.Miyakawa, S.S.Jeremiah, M.Osada, Y.Kimura, A.Ryo
    Journal of Proteomics, 255, 104501(2022).
  • Persistence of Robust Humoral Immune Response in Coronavirus Disease 2019 Convalescent Individuals Over 12 Months After Infection
    K.Miyakawa, S.Kubo, S.S.Jeremiah, H.Go, Y.Yamaoka, N.Ohtake, H.Kato, S.Ikeda, T.Mihara, I.Matsuba, N.Sanno, M.Miyakawa, M.Shinkai, T.Miyazaki, T.Ogura, S.Ito, T.Kaneko, K.Yamamoto, A.Goto, A.Ryo
    Open Forum Infectious Diseases, 9(2), ofab626(2022).
  • All-Trans Retinoic Acid Exhibits Antiviral Effect against SARS-CoV-2 by Inhibiting 3CLpro Activity
    T.Morita, K.Miyakawa, S.S.Jeremiah, Y.Yamaoka, M.Sada, T.Kuniyoshi, J.Yang, H.Kimura, A.Ryo
    Viruses, 13(8), 1669(2021).
  • Rapid detection of neutralizing antibodies to SARS-CoV-2 variants in post-vaccination sera
    K.Miyakawa, J.S.Stanleyraj, H.Kato, Y.Yamaoka, H.Go, S.Yajima, T.Shimada, T.Mihara, A.Goto, T.Yamanaka, A.Ryo
    Journal of Molecular Cell Biology, mjab050(2021).
  • Combining IL-6 and SARS-CoV-2 RNAaemiabased risk stratification for fatal outcomes of COVID-19
    R.Saji, M.Nishii, K.Sakai, K.Miyakawa, Y.Yamaoka, T.Ban, T.Abe, Y.Ohyama, K.Nakajima, T.Hiromi, R.Matsumura, N.Suzuki, H.Taniguchi, T.Otsuka, Y.Oi, F.Ogawa, M.Uchiyama, K.Takahashi, M.Iwashita, Y.Kimura, S.Fujii, R.Furuya, T.Tamura, A.Ryo, I.Takeuchi
    PLoSONE 16(8): e0256022(2021).
  • Evaluation of a combination protocol of CT-first triage and active telemedicine methods by a selected team tackling COVID-19: An experimental research study
    S.Miyake, T.Higurashi, H.Katoa, Y.Yamaoka, T.Kessoku, S.Kato, F.Ogawa, Y.Oia, A.Nakajima, T.Yamamoto, I.Takeuchi, A.Ryoe, S.Maeda
    Journal of Infection and Public Health, 14(9), 1212–1217(2021).
  • Highly specific monoclonal antibodies and epitope identification against SARS-CoV-2 nucleocapsid protein for antigen detection tests
    Y.Yamaoka, K.Miyakawa, S.S.Jeremiah, R.Funabashi, K.Okudela, S.Kikuchi, J.Katada, A.Wada, T.Takei, M.Nishi, K.Shimizu, H.Ozawa, S.Usuku, C.Kawakami, N.Tanaka, T.Morita, H.Hayashi, H.Mitsui, K.Suzuki, D.Aizawa, Y.Yoshimura, T.Miyazaki, E.Yamazaki, T.Suzuki, H.Kimura, H.Shimizu, N.Okabe, H.Hasegawa, A. Ryo
    Cell Reports Medicine(2021).  doi: 10.1016/j.xcrm.2021.100311
  • Sustained Neutralizing Antibodies 6 Months Following Infection in 376 Japanese COVID-19 Survivors
    A.Goto, H.Go, K.Miyakawa, Y.Yamaoka, N.Ohtake, S.Kubo, S.S.Jeremiah, T.Mihara, K.Senuki, T.Miyazaki, S.Ikeda, T.Ogura, H.Kato, I.Matsuba, N.Sanno, M.Miyakawa, H.Ozaki, M.Kikuoka, Y.Ohashi, A.Ryo, T.Yamanaka
    frontiers in Microbiology(2021). doi: 10.3389/fmicb.2021.661187
  • Severe acute respiratory syndrome coronavirus 2 prevalence in saliva and gastric and intestinal fluid in patients undergoing gastrointestinal endoscopy in coronavirus disease 2019 endemic areas: Prospective cross-sectional study in Japan
    S.Miyake, K.Ashikari, S.Kato, T.Takatsu, H.Kuwashima, H.Kaneko, K.Nagai, I.Watari, T.Sato, Y.Yamaoka, T.Yamamoto, A.Ryo, S.Maeda, A.Nakajima, T.Higurashi
    Digestive Endoscopy(2021), doi: 10.1111/den.13945
  • Development of an Automated Chemiluminescence Assay System for Quantitative Measurement of Multiple Anti-SARS-CoV-2 Antibodies
    S.Kubo, N.Ohtake, K.Miyakawa, S.Stanleyraj Jeremiah, Y.Yamaoka, K.Murohashi, E.Hagiwara, T.Mihara, A.Goto, E.Yamazaki, T.Ogura, T.Kaneko, T.Yamanaka, A.Ryo
    Frontiers in Microbiology, 11,  Article 628281(2021).
  • Development of Monoclonal Antibodies and Antigen-Capture ELISA for Human Parechovirus Type 3
    K.Goto, Y.Yamaoka, H.Khatun, K.Miyakawa, M.Nishi, N.Nagata, T.Yanaoka, H.Kimura, A.Ryo
    Microorganisms, 8, 1437(2020).
  • Rapid multiplex microfiber-based immunoassay for anti-MERS-CoV antibody detection
    C.F.O.Hoy, K.Kushiro, Y.Yamaoka, A.Ryo, M.Takai
    Sensing and Bio-Sensing Research, 26, Article 100304(2019).
  • Production and characterization of monoclonal antibodies specific for major capsid VP1 protein of trichodysplasia spinulosa associated polyomavirus
    H.Khatun, Y.Yamaoka, Y.Matsushima, S.Matsunaga, H.Kimura, J.Ho, M.Shuda, A.Ryo
    Microbiology and Immunology, 62(12),763-773(2018).
  • Development of a cell-based assay to identify hepatitis B virus entry inhibitors targeting the sodium taurocholate cotransporting polypeptide
    K. Miyakawa, S. Matsunaga, Y. Yamaoka, M. Dairaku, K. Fukano, H. Kimura, T. Chimuro, H. Nishitsuji, K. Watashi, K. Shimotohno, T. Wakita, A. Ryo
    Oncotarget, 9(34), 23681-23694 (2018).
  • Development of a bench-top extracleanroom for DNA amplification
    H. Takahashi, T. Satoh, H. Kanahara, Y. Kubota, T. Hirose, H. Yamazaki, K. Yamamoto, Y. Okamura, T. Suzuki, T. Kobori
    BioTechnique, 61(1), 42-46 (2016).
  • Discrimination of rat Brunner's gland carbohydrate antigens by site-specific monoclonal antibodies
    T. Chimuro, H. Kuroyama, Y. Goso, K. Ishihara, M. Kurihara
    Carbohydrate Research, 432, 76-82 (2016).
  • Development of Monoclonal Antibody and Diagnostic Test for Middle East Respiratory Syndrome Coronavirus Using Cell-Free Synthesized Nucleocapsid Antigen
    Y. Yamaoka, S. Matsuyama, S. Fukushi, S. Matsunaga, Y. Matsushima, H. Kuroyama, H. Kimura, M. Takeda, T. Chimuro, A. Ryo
    Frontiers in Microbiology, 7, 509 (2016).
  • Preparation of Phi29 DNA Polymerase Free of Amplifiable DNA Using Ethidium Monoazide, an Ultraviolet-Free Light-Emitting Diode Lamp and Trehalose
    H. Takahashi, H. Yamazaki, S. Akanuma, H. Kanahara, T. Saito, T. Chimuro, T. Kobayashi, T. Ohtani, K. Yamamoto, S. Sugiyama, T. Kobori
    PLOS ONE, 9(2), e82624/1-e82624/9 (2014).

Diagnostics

  • Development of highly sensitive and rapid antigen detection assay for diagnosis of COVID-19 utilizing optical waveguide immunosensor
    R.Funabashi, K.Miyakawa, Y.Yamaoka, S.Yoshimura, S.Yamane, J.S.Stanleyraj, K.Shimizu, H.Ozawa, C.Kawakami, S.Usuku, N.Tanaka, E.Yamazaki, H.Kimura, H.Hasegawa, A.Ryo
    Journal of Molecular Cell Biology ,mjab037(2021).