Organic synthesis and catalysts

• Asymmetric Hydrogenation of α‑Alkyl-Substituted β‑Keto Esters and Amides through Dynamic Kinetic Resolution
  T.Yurino, R.Nishihara, T.Yasuda, S.Yang, N.Utsumi, T.Katayama, N.Arai, T.Ohkuma
  Organic Letters, 26(14), 2872-2876(2024). https://doi.org/10.1021/acs.orglett.3c04036

• Asymmetric Reductive Amination of α‑Keto Acids Using Ir-Based Hydrogen Transfer Catalysts: An Access to Unprotected Unnatural α‑Amino Acids
  T.Yajima, A.Katayama, T.Ito, T.Kawada, K.Yabushita, T.Yasuda, T.Ohta, T.Katayama, N.Utsumi, Y.Kayaki, S.Kuwata
  Organic Letters, 26(7), 1426−1431(2024). https://doi.org/10.1021/acs.orglett.3c04378

• Apparatus for ammonia removal in livestock farms based on copper hexacyanoferrate granules
  K.Minami , A.Takahashi, K.Sakurai, H.Mikasa, M.Takasaki, N.Doshu, K.Aoyama, T.Nakamura, R.IaIwai, T.Kawamoto
  Biosystems Engineering, 216, 98-107(2022).https://doi.org/10.1016/j.biosystemseng.2022.02.002

• Development of an Efficient Method for the Synthesis of Chiral Amines by Using New Chiral Iridium Catalyst.
  T.Kawada, T.Katayama
  THE CHEMICAL TIMES, 264, 26-31 (2022).

• Asymmetric Transfer Hydrogenative Amination of Benzylic Ketones Catalyzed by Cp*Ir(III) Complexes Bearing a Chiral N-(2-Picolyl)sulfonamidato Ligand
  T.Kawada, K.Yabushita, T.Yasuda, T.Ohta, T.Yajima, K.Tanaka, N.Utsumi, M.Watanabe, K.Murata, Y.Kayaki, S.Kuwata, and T.Katayama
  The Journal of Organic Chemistry, 87(13), 8458-8468(2022)

• Double-Helix Supramolecular Nanofibers Assembled from Negatively Curved Nanographenes
  K.Kato, K.Takaba, S.M-Yonekura, N.Mitoma, Y.Nakanishi, T.Nishihara, T.Hatakeyama, T.Kawada, Y.Hijikata, J.Pirillo, L.T. Scott, K.Yonekura, Y.Segawa, K.Itami
  Journal of The American Chemical Society,  doi;10.1021/jacs.1c00863

• Reductive Amination of Ketonic Compounds Catalyzed by Cp*Ir(III)　Complexes Bearing a Picolinamidato Ligand
  K.Tanaka, T.Miki, K.Murata, A.Yamaguchi, Y.Kayaki, S.Kuwata, T.Ikariya, M.Watanabe
  The Journal of Organic Chemistry, 84, 10962-10977(2019).

• Asymmetric Hydrogenation of Polysubstituted Aromatic Ketones Catalyzed by the DIPSkewphos/PICA Derivative–Ruthenium(II) Complexes
  N.Utsumi, N.Arai, K.Kawaguchi, T.Katayama, T.Yasuda, K.Murata, T.Ohkuma
  ChemCatChem, 10(18), 3955-3959, 2018.

• Computationally-Led Ligand Modification using Interplay between Theory and Experiments: Highly Active Chiral Rhodium Catalyst Controlled by Electronic Effects and CH-π Interactions
  T. Korenaga, R. Sasaki, T. Takemoto, T. Yasuda, M. Watanabe
  Advanced Synthesis & Catalysis, 360, 322-333,(2018).

• Palladium-Catalyzed Decarbonylative Cross-Coupling of Azinecarboxylates with Arylboronic Acids
  K. Muto, T. Hatakeyama, K. Itami, J. Yamaguchi
  Organic Letters, 18(19), 5106-5109 (2016).

• C-H arylation and alkenylation of imidazoles by nickel catalysis : solvent-accelerated imidazole C-H activation
  K. Muto, T. Hatakeyama, J. Yamaguchi, K. Itami
  Chemical Science, 6, 6792-6798 (2015).

• Hydrogenation of nitroarenes with palladium nanoparticles stabilized by alkyne derivatives in homogeneous phase
  N. Arai, N. Onodera, A. Dekita, J. Hori, T. Ohkuma
  Tetrahedron Letters, 56(25), 3913-3915 (2015).

Organic materials

• Novel Hole-Transporting Materials with High Triplet Energy for Highly Efficient and Stable Organic Light-Emitting Diodes
  H. Fukagawa, T. Shimizu, H. Kawano, S. Yui, T. Shinnnai, A. Iwai, K. Tsuchiya, T. Yamamoto
  The Jounal of Physical Chemistry C, 120(33), 18748-18755 (2016).

Inorganic materials

• Apparatus for ammonia removal in livestock farms based on copper hexacyanoferrate granules
  K.Minami , A.Takahashi, K.Sakurai, H.Mikasa, M.Takasaki, N.Doshu, K.Aoyama, T.Nakamura, R.IaIwai, T.Kawamoto
  Biosystems Engineering Volume, 216, 98-107(2022).

• Iron Chromatographic Decontamination of ¹³⁷Cs-enriched Fly Ash Using Poly(vinyl alcohol)-bound Copper Ferrocyanide as Cs Adsorbent
  T.Ichikawa, K.Yamada, R.Iwai, Y.Kanazawa
  Journal of the Society for Remediation of Radioactive Contamination in the Environment, 8(2), 55-66(2020).

• Analysis of Cs-adsorption behavior using a column filled with microcapsule beads of potassium copper hexacyanoferrate
  G. Kido, M. Takasaki, K. Minami, H. Tanaka, H. Ogawa, T. Kawamoto, K. Yoshino
  Journal of nuclear science and technology, 54(11), 1157-1162 (2017).

• Decomposition of Iron Hexacyabnoferrate Microcapsule Beads Using Superheated Steam
  K. M. Lee, M. Asai, T. Uchida, T. Kawamoto, K. Minami, A. Takahashi, D. Parajuli, G. Kido, M. Takasaki, K. Yoshino, H. Tanaka
  Chemistry Letters, 45(6), 670-672 (2016).

• Improved adsorption properties of granulated copper hexacyanoferrate with multi-scale porous networks
  K. M. Lee, T. Kawamoto, K. Minami, A. Takahashi, D. Parajuli, G. Kido, K. Yoshino, H. Tanaka
  RSC Advances, 6, 16234-16238 (2016).

• Comparative study of the factors associated with the application of metal hexacyanoferrates for environmental Cs decontamination
  D. Parajuli, A. Takahashi, H. Noguchi, A. Kitajima, H. Tanaka, M. Takasaki, K. Yoshino, T. Kawamoto
  Chemical Engineering Journal, 283, 1322-1328 (2016).

• Application of Prussian blue nanoparticles for the radioactive Cs decontamination in Fukushima region
  D.Parajuli, A.Kitajima, A.Takahashi, H.Tanaka, H.Ogawa, Y.Hakuta, K.Yoshino, T.Funahashi, M.Yamaguchi, M.Osada, T.Kawamoto
  Journal of Environmental Radioactivity, 151, 233-237 (2016).

• Prussian blue (PB) granules for cesium (Cs) removal from drinking water
  G. Ru. Chen, Y. R. Chang, X. Liu, T. Kawamoto, H. Tanaka, A. Kitajima, D. Parajuli, M. Takasaki, K. Yoshino, M. L. Chen, Y. K. Lo, Z. Lei, D. J. Lee
  Separation and Purification Technology, 143, 146-151 (2015).

Cell culture

• Activation of cAMP (EPAC2)　signaling pathway promotes hepatocyte attachment
  G.A.Helena, T.Watanabe, Y.Kato, N.Shiraki, S.Kume
  Scientific Reports | (2023) 13:12352, https://doi.org/10.1038/s41598-023-39712-3

• Generation of human-induced pluripotent stem cell-derived functional enterocyte-like cells for pharmacokinetic studies
  S.Yoshida, T.Honjo, K.Iino, R.Ishibe, S.Leo, T.Shimada, T.Watanabe, M.Ishikawa, K.Maeda, H.Kusuhara, N.Shiraki, S.Kume
  Stem Cell Reports, Vol.16, 1–14(2021).

• A live imaging-friendly slice culture method using collagen membranes
  A.Ogaki, T.Araki, M.Ishikawa, Y.Ikegaya, R.Koyama
  Neuropsychopharmacology Reports, 40, 307–313(2020).

• Multi-laboratory Validation Study of the Vitrigel-Eye Irritancy Test Method as an Alternative to In Vivo Eye Irritation Testing
  H.Kojima, H.Yamaguchi, T.Sozu, N.Kleinstreuer, L.Chae-Hyung, W.Chen, M.Watanabe, T.Fukuda, K.Yamashita, T.Takezawa
  Alternatives to Laboratory Animals, 47(3-4),140-157(2019).

• Collagen vitrigel promotes hepatocytic differentiation of induced　pluripotent stem cells into functional hepatocyte-like cells
  S.Nakai, I.Shibata, T.Shitamichi, H.Yamaguchi, N.Takagi, T.Inoue, T.Nakagawa, J.Kiyokawa, S.Wakabayashi, T.Miyoshi, E.Higashi, S.Ishida, N.Shiraki, S.Kume
  Biology Open , 8, bio042192(2019).

• Fabrication of a corneal model composed of corneal epithelial and endothelial cells via a collagen vitrigel membrane functioned as an acellular stroma and its application to the corneal permeability test of chemicals
  H. Yamaguchi, T. Takezawa
  Drug Metabolism and Disposition, 46(11), 1684-1691(2018).

• Predictive performance of the Vitrigel-eye irritancy test method using 118 chemicals
  H. Yamaguchi, H. Kojima, T. Takezawa
  Journal of Applied Toxicology, 36(8), 1025-1037 (2016).

• Fluid dwell impact induces peritoneal fibrosis in the peritoneal cavity reconstructed in vitro
  Aoki, M. Noguchi, T. Takezawa, S. Ikeda, K. Uchihashi, H. Kuroyama, T.Cimuro, S. Toda
  Journal of Artificial Organs, 19(1), 87-96 (2016).

Genetic engineering / Other

• Development of a contacting transwell co-culture system for the in vitro propagation of primary central nervous system lymphoma
  M.Nishi, K.Tateishi, J.S.Sundararaj, Y.Ino, Y.Nakai, Y.Hatayama, Y.Yamaoka, Y.Mihana, K.Miyakawa, H.Kimura, Y.Kimura, T.Yamamoto, A.Ryo
  Frontiers in Cell and Developmental Biology, doi: 10.3389/fcell.2023.1275519

• Integrated tandem affinity protein purification usingthe polyhistidine plus extra 4 amino acids (HiP4) tag system
  Y.Ino, Y.Yamaoka, K.Tanaka, K.Miyakawa, M.Nishi, Y.Hatayama, H.Kimura, Y.Kimura, A.Ryo
  Proteomics, 2023 Jun;23(11):e2200334. doi: 10.1002/pmic.202200334

• Diagnotics for COVID-19
  Y.Yamaoka
  THE CHEMICAL TIMES, 268, 2-7 (2023).

• Generation and Utilization of a Monoclonal Antibody against Hepatitis B Virus Core Protein for a Comprehensive Interactome Analysis
  Y.Nakai, K.Miyakawa, Y.Yamaoka, Y. Hatayama, M.Nishi, H.Suzuki, H.Kimura, H.Takahashi, Y.Kimura, A.Ryo
  Microorganisms, 10, 2381(2022).

• Development of a Monoclonal Antibody Targeting HTLV-1 Envelope gp46 Glycoprotein and Its Application to Near-Infrared Photoimmuno-Antimicrobial Strategy
  Y. Hatayama, Y.Yamaoka, T.Morita, S.S.Jeremiah, K.Miyakawa, M.Nishi, Y.Kimura, M.Mitsunaga, T.Iwase, H.Kimura, N.Yamamoto, A.Takaori-Kondo, H.Hasegawa, A.Ryo
  Viruses, 14, 2153 (2022).

• Development of Parallel Reaction Monitoring Mass Spectrometry Assay for the Detection of Human Norovirus Major Capsid Protein
  Y.Kimura, J.Shin, Y.Nakai, M.Takahashi, Y.Ino, T.Akiyama, K.Goto, N.Nagata, Y.Yamaoka, K.Miyakawa, H.Kimura, A.Ryo
  Viruses, 14(7), 1416(2022).

• Characterization and Utilization of Disulfide-Bonded SARS-CoV-2 Receptor Binding Domain of Spike Protein Synthesized by Wheat Germ Cell-Free Production System
  Y.Yamaoka, S.S.Jeremiah, R.Funabashi, K.Miyakawa, T.Morita, Y.Mihana, H.Kato, A.Ryo
  Viruses, 14(7), 1461(2022).

• Vaccine-induced humoral response against SARS-CoV-2 dramatically declined but cellular immunity possibly remained at 6 months post BNT162b2 vaccination
  H.Kato, K.Miyakawa, N.Ohtake, Y.Yamaoka, S.Yajima, E.Yamazaki, T.Shimada, A.Goto, H.Nakajima, A.Ryo
  Vaccine, 40, 2652–2655(2022).

• Molecular and Epidemiological Characterization of Emerging Immune-Escape Variants of SARS-CoV-2
  K.Miyakawa, S.S.Jeremiah, Y.Yamaoka, T.Koyama, R.Tokumasu, M.Kudo, H.Kato, A.Ryo
  frontiers in Medicine, 10(2022).

• Antibody titers against the Alpha, Beta, Gamma, and Delta variants of SARS-CoV-2 induced by BNT162b2 vaccination measured using automated chemiluminescent enzyme immunoassay
  H.Kato, K.Miyakawa, N.Ohtake, H.Go, Y.Yamaoka, S.Yajima, T.Shimada, A.Goto, H.Nakajima, A.Ryo
  Journal of Infection and Chemotherapy, 28, 273–278(2022).

• Phosphopeptide enrichment using Phos-tag technology reveals functional phosphorylation of the nucleocapsid protein of SARS-CoV-2
  Y.Ino, M.Nishi, Y.Yamaoka, K.Miyakawa, S.S.Jeremiah, M.Osada, Y.Kimura, A.Ryo
  Journal of Proteomics, 255, 104501(2022).

• Persistence of Robust Humoral Immune Response in Coronavirus Disease 2019 Convalescent Individuals Over 12 Months After Infection
  K.Miyakawa, S.Kubo, S.S.Jeremiah, H.Go, Y.Yamaoka, N.Ohtake, H.Kato, S.Ikeda, T.Mihara, I.Matsuba, N.Sanno, M.Miyakawa, M.Shinkai, T.Miyazaki, T.Ogura, S.Ito, T.Kaneko, K.Yamamoto, A.Goto, A.Ryo
  Open Forum Infectious Diseases, 9(2), ofab626(2022).

• All-Trans Retinoic Acid Exhibits Antiviral Effect against SARS-CoV-2 by Inhibiting 3CLpro Activity
  T.Morita, K.Miyakawa, S.S.Jeremiah, Y.Yamaoka, M.Sada, T.Kuniyoshi, J.Yang, H.Kimura, A.Ryo
  Viruses, 13(8), 1669(2021).

• Rapid detection of neutralizing antibodies to SARS-CoV-2 variants in post-vaccination sera
  K.Miyakawa, J.S.Stanleyraj, H.Kato, Y.Yamaoka, H.Go, S.Yajima, T.Shimada, T.Mihara, A.Goto, T.Yamanaka, A.Ryo
  Journal of Molecular Cell Biology, mjab050(2021).

• Combining IL-6 and SARS-CoV-2 RNAaemiabased risk stratification for fatal outcomes of COVID-19
  R.Saji, M.Nishii, K.Sakai, K.Miyakawa, Y.Yamaoka, T.Ban, T.Abe, Y.Ohyama, K.Nakajima, T.Hiromi, R.Matsumura, N.Suzuki, H.Taniguchi, T.Otsuka, Y.Oi, F.Ogawa, M.Uchiyama, K.Takahashi, M.Iwashita, Y.Kimura, S.Fujii, R.Furuya, T.Tamura, A.Ryo, I.Takeuchi
  PLoSONE 16(8): e0256022(2021).

• Evaluation of a combination protocol of CT-first triage and active telemedicine methods by a selected team tackling COVID-19: An experimental research study
  S.Miyake, T.Higurashi, H.Katoa, Y.Yamaoka, T.Kessoku, S.Kato, F.Ogawa, Y.Oia, A.Nakajima, T.Yamamoto, I.Takeuchi, A.Ryoe, S.Maeda
  Journal of Infection and Public Health, 14(9), 1212–1217(2021).

• Highly specific monoclonal antibodies and epitope identification against SARS-CoV-2 nucleocapsid protein for antigen detection tests
  Y.Yamaoka, K.Miyakawa, S.S.Jeremiah, R.Funabashi, K.Okudela, S.Kikuchi, J.Katada, A.Wada, T.Takei, M.Nishi, K.Shimizu, H.Ozawa, S.Usuku, C.Kawakami, N.Tanaka, T.Morita, H.Hayashi, H.Mitsui, K.Suzuki, D.Aizawa, Y.Yoshimura, T.Miyazaki, E.Yamazaki, T.Suzuki, H.Kimura, H.Shimizu, N.Okabe, H.Hasegawa, A. Ryo
  Cell Reports Medicine(2021).  doi: 10.1016/j.xcrm.2021.100311

• Sustained Neutralizing Antibodies 6 Months Following Infection in 376 Japanese COVID-19 Survivors
  A.Goto, H.Go, K.Miyakawa, Y.Yamaoka, N.Ohtake, S.Kubo, S.S.Jeremiah, T.Mihara, K.Senuki, T.Miyazaki, S.Ikeda, T.Ogura, H.Kato, I.Matsuba, N.Sanno, M.Miyakawa, H.Ozaki, M.Kikuoka, Y.Ohashi, A.Ryo, T.Yamanaka
  frontiers in Microbiology(2021). doi: 10.3389/fmicb.2021.661187

• Severe acute respiratory syndrome coronavirus 2 prevalence in saliva and gastric and intestinal fluid in patients undergoing gastrointestinal endoscopy in coronavirus disease 2019 endemic areas: Prospective cross-sectional study in Japan
  S.Miyake, K.Ashikari, S.Kato, T.Takatsu, H.Kuwashima, H.Kaneko, K.Nagai, I.Watari, T.Sato, Y.Yamaoka, T.Yamamoto, A.Ryo, S.Maeda, A.Nakajima, T.Higurashi
  Digestive Endoscopy(2021), doi: 10.1111/den.13945

• Development of an Automated Chemiluminescence Assay System for Quantitative Measurement of Multiple Anti-SARS-CoV-2 Antibodies
  S.Kubo, N.Ohtake, K.Miyakawa, S.Stanleyraj Jeremiah, Y.Yamaoka, K.Murohashi, E.Hagiwara, T.Mihara, A.Goto, E.Yamazaki, T.Ogura, T.Kaneko, T.Yamanaka, A.Ryo
  Frontiers in Microbiology, 11,  Article 628281(2021).

• Zika virus protease induces caspase-independent pyroptotic cell death by directly cleaving gasdermin D
  Y.Yamaoka, S.Matsunaga, SS.Jeremiah, M.Nishi, K.Miyakawa, T.Morita, H.Khatun, H.Shimizu, N.Okabe, H.Kimura, H.Hasegawa, A.Ryo
  Biochemical and Biophysical Research Communications, 534 , 666-671(2021).

• Potent antiviral effect of silver nanoparticles on SARS-CoV-2
  SS.Jeremiah, K. Miyakawa, T.Morita, Y.Yamaoka, A.Ryo
  Biochemical and Biophysical Research Communications, 533(1), 195-200(2020).

• Development of Monoclonal Antibodies and Antigen-Capture ELISA for Human Parechovirus Type 3
  K.Goto, Y.Yamaoka, H.Khatun, K.Miyakawa, M.Nishi, N.Nagata, T.Yanaoka, H.Kimura, A.Ryo
  Microorganisms, 8, 1437(2020).

• Rapid quantitative screening assay for SARS-CoV-2 neutralizing antibodies using HiBiT-tagged virus-like particles
  K.Miyakawa, S.S.Jeremiah, N.Ohtake, S.Matsunaga, Y.Yamaoka, M.Nishi, T.Morita, R.Saji, M.Nishii, H.Kimura, H.Hasegawa, I.Takeuchi, A.Ryo
  Journal of Molecular Cell Biology (2020).  doi:10.1093/jmcb/mjaa047

• Whole Nucleocapsid Protein of Severe Acute Respiratory Syndrome Coronavirus 2 May Cause False-Positive Results in Serological Assays
  Y.Yamaoka, S. S. Jeremiah, K.Miyakawa, R.Saji, M.Nishii, I.Takeuchi, A.Ryo
  Clinical Infectious Diseaes(2020). doi:10.1093/cid/ciaa637

• Prolyl Isomerase Pin1 Regulates the Stability of Hepatitis B Virus Core Protein
  M.Nishi, K.Miyakawa, S.Matsunaga, H.Khatun, Y.Yamaoka, K.Watashi, M.Sugiyama, H.Kimura, T.Wakita, A.Ryo
  Frontiers in Cell and Developmental Biology, 8(2020). doi:10.3389/fcell.2020.00026

• Rapid multiplex microfiber-based immunoassay for anti-MERS-CoV antibody detection
  C.F.O.Hoy, K.Kushiro, Y.Yamaoka, A.Ryo, M.Takai
  Sensing and Bio-Sensing Research, 26, Article 100304(2019).

• Production and characterization of monoclonal antibodies specific for major capsid VP1 protein of trichodysplasia spinulosa associated polyomavirus
  H.Khatun, Y.Yamaoka, Y.Matsushima, S.Matsunaga, H.Kimura, J.Ho, M.Shuda, A.Ryo
  Microbiology and Immunology, 62(12),763-773(2018).

• Development of a cell-based assay to identify hepatitis B virus entry inhibitors targeting the sodium taurocholate cotransporting polypeptide
  K. Miyakawa, S. Matsunaga, Y. Yamaoka, M. Dairaku, K. Fukano, H. Kimura, T. Chimuro, H. Nishitsuji, K. Watashi, K. Shimotohno, T. Wakita, A. Ryo
  Oncotarget, 9(34), 23681-23694 (2018).

• Development of a bench-top extracleanroom for DNA amplification
  H. Takahashi, T. Satoh, H. Kanahara, Y. Kubota, T. Hirose, H. Yamazaki, K. Yamamoto, Y. Okamura, T. Suzuki, T. Kobori
  BioTechnique, 61(1), 42-46 (2016).

• Discrimination of rat Brunner's gland carbohydrate antigens by site-specific monoclonal antibodies
  T. Chimuro, H. Kuroyama, Y. Goso, K. Ishihara, M. Kurihara
  Carbohydrate Research, 432, 76-82 (2016).

• Development of Monoclonal Antibody and Diagnostic Test for Middle East Respiratory Syndrome Coronavirus Using Cell-Free Synthesized Nucleocapsid Antigen
  Y. Yamaoka, S. Matsuyama, S. Fukushi, S. Matsunaga, Y. Matsushima, H. Kuroyama, H. Kimura, M. Takeda, T. Chimuro, A. Ryo
  Frontiers in Microbiology, 7, 509 (2016).

• Preparation of Phi29 DNA Polymerase Free of Amplifiable DNA Using Ethidium Monoazide, an Ultraviolet-Free Light-Emitting Diode Lamp and Trehalose
  H. Takahashi, H. Yamazaki, S. Akanuma, H. Kanahara, T. Saito, T. Chimuro, T. Kobayashi, T. Ohtani, K. Yamamoto, S. Sugiyama, T. Kobori
  PLOS ONE, 9(2), e82624/1-e82624/9 (2014).

Diagnostics

• Development of highly sensitive and rapid antigen detection assay for diagnosis of COVID-19 utilizing optical waveguide immunosensor
  R.Funabashi, K.Miyakawa, Y.Yamaoka, S.Yoshimura, S.Yamane, J.S.Stanleyraj, K.Shimizu, H.Ozawa, C.Kawakami, S.Usuku, N.Tanaka, E.Yamazaki, H.Kimura, H.Hasegawa, A.Ryo
  Journal of Molecular Cell Biology ,mjab037(2021).

Microbial testing

• Performance evaluation of C. Diff selective multiplication broth medium without anaerobic culture
  S.Ookawachi, T.Natori, N.Uchida, E.Arai, K.Horiuchi
  The Journal of the Japanese Society for Clinical Microbiology, 32(4), 63-66(2022).