M-GGMC-1(HIK1083)
Anti-Mucin Monoclonal AntibodyRecognizing Gastric Gland Mucous Cells
M-GGMC-1 is a monoclonal antibody that recognizes the peripheral a-linked GlcNAc residue present in the carbohydrate moiety of the mucin molecule and reacts with oligosaccharides bearing a peripheral a-GlcNAc structure.2 M-GGMC-1 recognizes the gastric gland mucous cell-derived mucin and the reactivity of M-GGMC-1 is similar to the Paradoxical concanavalin A staining method.4 It is indicated that M-GGMC-1 is a useful tool for early diagnosis of mucinous minimal deviation adenocarcinoma of the uterus (adenoma malignum) or bronchioloalveolar carcinoma with secreting cells.3, 1
1 Honda, T., Ishii, K., Ota, H., Nakamura, N., Kubo, K. and Kasuyama, T. (1998) Am. J. Clin. Pathol. 109, 432-430
2 Ishihara, K., Kurihara, M., Goso, Y., Urata, T., Ota, H., Katsuyama, T. and Hotta, K. (1996) Biochem.J. 318, 409-416
3 Ishii, K., Hosaka, N., Toki, T., Momose, M., Hidaka, E,. Tsuchiya, S. and Katsuyama, T. (1998) Virchows Arch. 432, 315-322
4 Nakamura, N., Ota, H., Katsuyama, T., Ishihara, K., Kurihara, M. and Hotta, K. (1998) J.Histchem. Cytochem. 46, 793-801
*Warnig and Caution: This product is intended FOR RESEARCH USE ONLY, not for use in diagnostic or therapeutic procedures involving humans or animals.
Product information
| Product Form | Lyophilized powder of the clone culture supernatant containing 1 % bovine serum albumin and 3.1 % sodium azide. |
| Clone (Globulin class) |
HIK1083 (mouse IgM, kappa). |
| Immunogen | Rat gastric mucin. |
| Epitope | Mucin-type oligosaccharides bearing a peripheral α-GlcNAc structure. |
| Specificity | Mammalian gastric gland mucous cells (cardiac gland cells, mucous neck cells and pyloric gland cells), Brunner’s gland cells. |
| Application | Formalin-fixed paraffin-embedded section. |
| Recommendations on Use |
Reconstitute product with 1.0 mL of deionized or distilled water. Typical working dilution 1:5 – 1:50. The antibody dilutions are guidelines only: optimal dilutions should be determined by the individual laboratory. |
| Storage | Store lyophilized product at 4 ℃. For immediate use store reconstituted antibody at 4 ℃. For long-term storage aliquot antibody into smaller volumes and store at -20 ℃ or lower. |
Staining examples
Brochure
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