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研究発表/論文

当社はさまざまな分野において大学や公的機関、企業とともに積極的に共同研究を推し進め、その成果を論文等で発表しています。近年の発表について、その一部をご紹介いたします。

遺伝子工学関連/他

  • Highly specific monoclonal antibodies and epitope identification against SARS-CoV-2 nucleocapsid protein for antigen detection tests
    Y.Yamaoka, K.Miyakawa, S.S.Jeremiah, R.Funabashi, K.Okudela, S.Kikuchi, J.Katada, A.Wada, T.Takei, M.Nishi, K.Shimizu, H.Ozawa, S.Usuku, C.Kawakami, N.Tanaka, T.Morita, H.Hayashi, H.Mitsui, K.Suzuki, D.Aizawa, Y.Yoshimura, T.Miyazaki, E.Yamazaki, T.Suzuki, H.Kimura, H.Shimizu, N.Okabe, H.Hasegawa, A. Ryo
    Cell Reports Medicine(2021), doi:10.1016/j.xcrm.2021.100311
  • Sustained Neutralizing Antibodies 6 Months Following Infection in 376 Japanese COVID-19 Survivors
    A.Goto, H.Go, K.Miyakawa, Y.Yamaoka, N.Ohtake, S.Kubo, S.S.Jeremiah, T.Mihara, K.Senuki, T.Miyazaki, S.Ikeda, T.Ogura, H.Kato, I.Matsuba, N.Sanno, M.Miyakawa, H.Ozaki, M.Kikuoka, Y.Ohashi, A.Ryo, T.Yamanaka
    frontiers in Microbiology, doi: 10.3389/fmicb.2021.661187
  • Severe acute respiratory syndrome coronavirus 2 prevalence in saliva and gastric and intestinal fluid in patients undergoing gastrointestinal endoscopy in coronavirus disease 2019 endemic areas: Prospective cross-sectional study in Japan
    S.Miyake, K.Ashikari, S.Kato, T.Takatsu, H.Kuwashima, H.Kaneko, K.Nagai, I.Watari, T.Sato, Y.Yamaoka, T.Yamamoto, A.Ryo, S.Maeda, A.Nakajima, T.Higurashi
    Digestive Endoscopy, doi: 10.1111/den.13945
  • Zika virus protease induces caspase-independent pyroptotic cell death by directly cleaving gasdermin D
    Y.Yamaoka, S.Matsunaga, SS.Jeremiah, M.Nishi, K.Miyakawa, T.Morita, H.Khatun, H.Shimizu, N.Okabe, H.Kimura, H.Hasegawa, A.Ryo
    Biochemical and Biophysical Research Communications, 534 , 666-671(2021). doi: 10.1016/j.bbrc.2020.11.023
  • Potent antiviral effect of silver nanoparticles on SARS-CoV-2
    SS.Jeremiah, K. Miyakawa, T.Morita, Y.Yamaoka, A.Ryo
    Biochemical and Biophysical Research Communications, 533(1), 195-200(2020). doi: 10.1016/j.bbrc.2020.09.018
  • Development of Monoclonal Antibodies and Antigen-Capture ELISA for Human Parechovirus Type 3
    K.Goto, Y.Yamaoka, H.Khatun, K.Miyakawa, M.Nishi, N.Nagata, T.Yanaoka, H.Kimura, A.Ryo
    Microorganisms, 8, 1437(2020). doi: 10.3390/microorganisms8091437
  • Whole Nucleocapsid Protein of Severe Acute Respiratory Syndrome Coronavirus 2 May Cause False-Positive Results in Serological Assays
    Y.Yamaoka, S. S. Jeremiah, K.Miyakawa, R.Saji, M.Nishii, I.Takeuchi, A.Ryo
    Clinical Infectious Diseaes, (2020). doi:10.1093/cid/ciaa637
  • Prolyl Isomerase Pin1 Regulates the Stability of Hepatitis B Virus Core Protein
    M.Nishi, K.Miyakawa, S.Matsunaga, H.Khatun, Y.Yamaoka, K.Watashi, M.Sugiyama, H.Kimura, T.Wakita, A.Ryo
    Frontiers in Cell and Developmental Biology, 8(2020). doi:10.3389/fcell.2020.00026
  • Rapid multiplex microfiber-based immunoassay for anti-MERS-CoV antibody detection
    C.F.O.Hoy, K.Kushiro, Y.Yamaoka, A.Ryo, M.Takai
    Sensing and Bio-Sensing Research, 26, Article 100304(2019).
  • Production and characterization of monoclonal antibodies specific for major capsid VP1 protein of trichodysplasia spinulosa associated polyomavirus
    H.Khatun, Y.Yamaoka, Y.Matsushima, S.Matsunaga, H.Kimura, J.Ho, M.Shuda, A.Ryo
    Microbiology and Immunology, 62(12),763-773(2018).
  • Development of a cell-based assay to identify hepatitis B virus entry inhibitors targeting the sodium taurocholate cotransporting polypeptide
    K. Miyakawa, S. Matsunaga, Y. Yamaoka, M. Dairaku, K. Fukano, H. Kimura, T. Chimuro, H. Nishitsuji, K. Watashi, K. Shimotohno, T. Wakita, A. Ryo
    Oncotarget, 9(34), 23681-23694 (2018).
  • Development of a bench-top extracleanroom for DNA amplification
    H. Takahashi, T. Satoh, H. Kanahara, Y. Kubota, T. Hirose, H. Yamazaki, K. Yamamoto, Y. Okamura, T. Suzuki, T. Kobori
    BioTechnique, 61(1), 42-46 (2016).
  • Discrimination of rat Brunner's gland carbohydrate antigens by site-specific monoclonal antibodies
    T. Chimuro, H. Kuroyama, Y. Goso, K. Ishihara, M. Kurihara
    Carbohydrate Research, 432, 76-82 (2016).
  • Development of Monoclonal Antibody and Diagnostic Test for Middle East Respiratory Syndrome Coronavirus Using Cell-Free Synthesized Nucleocapsid Antigen
    Y. Yamaoka, S. Matsuyama, S. Fukushi, S. Matsunaga, Y. Matsushima, H. Kuroyama, H. Kimura, M. Takeda, T. Chimuro, A. Ryo
    Frontiers in Microbiology, 7, 509 (2016).
  • 微生物1細胞のゲノム解析に向けた全ゲノム増幅法の改良
    高橋宏和、山嵜裕之、小堀俊郎
    バイオサイエンスとインダストリー, 72(6), 492-493 (2014).
  • Preparation of Phi29 DNA Polymerase Free of Amplifiable DNA Using Ethidium Monoazide, an Ultraviolet-Free Light-Emitting Diode Lamp and Trehalose
    H. Takahashi, H. Yamazaki, S. Akanuma, H. Kanahara, T. Saito, T. Chimuro, T. Kobayashi, T. Ohtani, K. Yamamoto, S. Sugiyama, T. Kobori
    PLOS ONE, 9(2), e82624/1-e82624/9 (2014).

細胞培養関連

  • A live imaging-friendly slice culture method using collagen membranes
    A.Ogaki, T.Araki, M.Ishikawa, Y.Ikegaya, R.Koyama
    Neuropsychopharmacology Reports, 40, 307–313(2020).
  • Multi-laboratory Validation Study of the Vitrigel-Eye Irritancy Test Method as an Alternative to In Vivo Eye Irritation Testing
    H.Kojima, H.Yamaguchi, T.Sozu, N.Kleinstreuer, L.Chae-Hyung, W.Chen, M.Watanabe, T.Fukuda, K.Yamashita, T.Takezawa
    Alternatives to Laboratory Animals, 47(3-4),140-157(2019).
  • Collagen vitrigel promotes hepatocytic differentiation of induced pluripotent stem cells into functional hepatocyte-like cells
    S.Nakai, I.Shibata, T.Shitamichi, H.Yamaguchi, N.Takagi, T.Inoue, T.Nakagawa, J.Kiyokawa, S.Wakabayashi, T.Miyoshi, E.Higashi, S.Ishida, N.Shiraki, S.Kume
    Biology Open , 8, bio042192(2019).
  • Fabrication of a corneal model composed of corneal epithelial and endothelial cells via a collagen vitrigel membrane functioned as an acellular stroma and its application to the corneal permeability test of chemicals
    H. Yamaguchi, T. Takezawa
    Drug Metabolism and Disposition, 46(11), 1684-1691(2018).
  • 動物実験代替法における皮膚評価モデルの作製と評価
      コラーゲンビトリゲル膜チャンバーを用いた眼刺激性試験法

    竹澤俊明、山口宏之
    皮膚の安全性・有用性評価法、㈱技術情報協会、2018、pp. 73-77.
  • Predictive performance of the Vitrigel-eye irritancy test method using 118 chemicals
    H. Yamaguchi, H. Kojima, T. Takezawa
    Journal of Applied Toxicology, 36(8), 1025-1037 (2016).
  • Fluid dwell impact induces peritoneal fibrosis in the peritoneal cavity reconstructed in vitro
    Aoki, M. Noguchi, T. Takezawa, S. Ikeda, K. Uchihashi, H. Kuroyama, T.Cimuro, S. Toda
    Journal of Artificial Organs, 19(1), 87-96 (2016).
  • 三次元培養に適した新規細胞培養用器材 ad-MEDビトリゲル®
    高木信幸
    クリーンテクノロジー, 2014(3), 71-74 (2014).

診断試薬関連

  • 新型コロナウイルス感染症の検査診断法
    山岡悠太朗、梁明秀
    感染制御と予防衛生, 4(1), 9-15(2020).
  • 尿中カテコールアミン類及びその代謝物における酸性蓄尿用添加剤「酸性ユリメジャー・T」の適用評価
    中浦秀章、加藤雅子 、粗恭子、高笠信之
    THE CHEMICAL TIMES, 231, 13-17 (2014).

微生物検査関連

電気泳動関連/他

  • タンパク質検出用蛍光分子プローブの創製とハイスループット検出法への展開
    鈴木祥夫、高木信幸
    生物物理化学, 58(2),65-67 (2014).

有機合成・触媒関連

  • Double-Helix Supramolecular Nanofibers Assembled from Negatively Curved Nanographenes
    K.Kato, K.Takaba, S.M-Yonekura, N.Mitoma, Y.Nakanishi, T.Nishihara, T.Hatakeyama, T.Kawada, Y.Hijikata, J.Pirillo, L.T. Scott, K.Yonekura, Y.Segawa, K.Itami
    Journal of The American Chemical Society,  doi;10.1021/jacs.1c00863
  • Reductive Amination of Ketonic Compounds Catalyzed by Cp*Ir(III) Complexes Bearing a Picolinamidato Ligand
    K.Tanaka, T.Miki, K.Murata, A.Yamaguchi, Y.Kayaki, S.Kuwata, T.Ikariya, M.Watanabe
    The Journal of Organic Chemistry, 84, 10962-10977(2019).
  • Asymmetric Hydrogenation of Polysubstituted Aromatic Ketones Catalyzed by the DIPSkewphos/PICA Derivative–Ruthenium(II) Complexes
    N.Utsumi, N.Arai, K.Kawaguchi, T.Katayama, T.Yasuda, K.Murata, T.Ohkuma
    ChemCatChem, 10(18), 3955-3959, 2018.
  • Computationally-Led Ligand Modification using Interplay between Theory and Experiments: Highly Active Chiral Rhodium Catalyst Controlled by Electronic Effects and CH-π Interactions
    T. Korenaga, R. Sasaki, T. Takemoto, T. Yasuda, M. Watanabe
    Advanced Synthesis & Catalysis, 360, 322-333,(2018).
  • Palladium-Catalyzed Decarbonylative Cross-Coupling of Azinecarboxylates with Arylboronic Acids
    K. Muto, T. Hatakeyama, K. Itami, J. Yamaguchi
    Organic Letters, 18(19), 5106-5109 (2016).
  • C-H arylation and alkenylation of imidazoles by nickel catalysis : solvent-accelerated imidazole C-H activation
    K. Muto, T. Hatakeyama, J. Yamaguchi, K. Itami
    Chemical Science, 6, 6792-6798 (2015).
  • Hydrogenation of nitroarenes with palladium nanoparticles stabilized by alkyne derivatives in homogeneous phase
    N. Arai, N. Onodera, A. Dekita, J. Hori, T. Ohkuma
    Tetrahedron Letters, 56(25), 3913-3915 (2015).

有機材料関連

  • イオン性高分子ゲル化剤の開発
    髙﨑幹大
    月間ファインケミカル, 45(10), 47-55 (2016).
  • Novel Hole-Transporting Materials with High Triplet Energy for Highly Efficient and Stable Organic Light-Emitting Diodes
    H. Fukagawa, T. Shimizu, H. Kawano, S. Yui, T. Shinnnai, A. Iwai, K. Tsuchiya, T. Yamamoto
    The Jounal of Physical Chemistry C, 120(33), 18748-18755 (2016).

電子工業用薬品関連

無機材料関連

  • ポリビニルアルコールで造粒したフェロシアン化銅をCs吸着材に用いたイオンクロマトグラフィーによる137Cs濃縮飛灰の除染
    市川恒樹、山田一夫、岩井良太、金澤幸広
    環境放射能除染学会誌, 8(2), 55-66(2020).
  • Analysis of Cs-adsorption behavior using a column filled with microcapsule beads of potassium copper hexacyanoferrate
    G. Kido, M. Takasaki, K. Minami, H. Tanaka, H. Ogawa, T. Kawamoto, K. Yoshino
    Journal of nuclear science and technology, 54(11), 1157-1162 (2017).
  • Decomposition of Iron Hexacyabnoferrate Microcapsule Beads Using Superheated Steam
    K. M. Lee, M. Asai, T. Uchida, T. Kawamoto, K. Minami, A. Takahashi, D. Parajuli, G. Kido, M. Takasaki, K. Yoshino, H. Tanaka
    Chemistry Letters, 45(6), 670-672 (2016).
  • Improved adsorption properties of granulated copper hexacyanoferrate with multi-scale porous networks
    K. M. Lee, T. Kawamoto, K. Minami, A. Takahashi, D. Parajuli, G. Kido, K. Yoshino, H. Tanaka
    RSC Advances, 6, 16234-16238 (2016).
  • Comparative study of the factors associated with the application of metal hexacyanoferrates for environmental Cs decontamination
    D. Parajuli, A. Takahashi, H. Noguchi, A. Kitajima, H. Tanaka, M. Takasaki, K. Yoshino, T. Kawamoto
    Chemical Engineering Journal, 283, 1322-1328 (2016).
  • Prussian blue (PB) granules for cesium (Cs) removal from drinking water
    G. Ru. Chen, Y. R. Chang, X. Liu, T. Kawamoto, H. Tanaka, A. Kitajima, D. Parajuli, M. Takasaki, K. Yoshino, M. L. Chen, Y. K. Lo, Z. Lei, D. J. Lee
    Separation and Purification Technology, 143, 146-151 (2015).